Sep 29, 2020

Synthesis And Antibacterial Activity Of New Chiral N

synthesis and antibacterial activity of new chiral n

Abstract. A new series of N, \(N^{\prime }\)-bis-oxazolidinones-sulfone and 5-chloromethylsulfamoyl-oxazolidin-2-ones have been synthesized in three steps (carbamoylation, sulfamoylation and cyclization) starting from 1,3-dichloroporopan-2-ol, chlorosulfonyl isocyanate and primary or secondary amines.Synthesis has been carried out following simple methodology in excellent isolated yields.

Synthesis and antibacterial activity of new chiral N ...

We report here the design, synthesis, and antibacterial activities of novel classes of compounds containing chiral 1,3-oxazinan-2-ones and oxazolidinones as the basic core structures. These compounds are tertiary amines containing the core structures and two aryl substituents. Several of these molecules exhibit potent antibacterial activities against the tested Gram-positive bacteria, including

(PDF) Synthesis and antibacterial activity of new chiral N ...

The latter afforded new chiral 5-alkyl-3-(1′-benzenesulfonylpyrrolidin-2′-yl)-4,5-dihydro-1,2,4oxadiazin-6-ones in good chemical yields via intramolecular cyclization in the presence of one equivalent of NaH. These new compounds were evaluated for their antibacterial and antifungal activities using micro-dilution tests against some strains of bacteria and fungi. Our compounds showed an excellent antibacterial activity, which is better than the drug levofloxacin.

Synthesis and Antimicrobial Evaluation of Novel Chiral 2 ...

Simple and Efficient Synthesis of New Chiral N,N-Sulfonyl Bis-Oxazolidin-2-Ones 63 secondary amines and the linkage and the reticula- tionofbiomolecules,especiallyproteins.Thesecom-pounds are currently being evaluated for biological activity, and the results of these investigations will be reported in due course. EXPERIMENTAL All commercial chemicals and solvents were used as received. All ...

Synthesis and antimicrobial activity of chiral quaternary ...

Fluoronaphthyridines as antibacterial agents. 6. Synthesis and structure-activity relationships of new chiral 7-(1-, 3-, 4-, and 6-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)naphthyridine analogues of 7-[(1R,4R)-2,5- diazabicyclo[2.2.1]heptan-2-yl]-1-(1,1-dimethylethyl)-6-fluoro-1,4-dihy dro-4-oxo-1,8-naphthyridine-3-carboxylic acid. Influence of the configuration on blood pressure in dogs. A quinolone-class effect.

Synthesis and antibacterial activities of new quaternary ...

Synthesis and Antibacterial Activity of New Chiral Aminoalcohol and Benzimidazole Hybrids ChemistrySelect ( IF 1.716) Pub Date : 2020-04-20, DOI: 10.1002/slct.202000355 İlknur Çiçek; Turgay Tunç; Hatice Ogutcu; Suzan Abdurrahmanoglu; Aslıhan Günel; Nadir Demirel

Synthesis and Antimicrobial Activity of Imidazolium and ...

Read Book Synthesis And Antibacterial Activity Of New Chiral N Synthesis And Antibacterial Activity Of New Chiral N Yeah, reviewing a books synthesis and antibacterial activity of new chiral n could amass your close associates listings. This is just one of the solutions for you to be successful. As understood, expertise does not recommend that you have extraordinary points. Comprehending as ...

Synthesis and Antibacterial Activity of Peptide ...

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Synthesis of Optically Active Ferrocene‐Containing ...

Synthesis and antibacterial activity of new chiral N-sulfamoyloxazolidin-2-ones. Journal of Chemical Sciences 2016, 128 (1) , 85-91. DOI: 10.1007/s12039-015-1004-x. James R. McCarthy. A convenient synthesis of the antibacterial agent linezolid.

Synthesis and antimalarial activity of novel chiral and ...

Synthesis of Novel Chiral Heterocyclic Compounds for Antibacterial Agents and Peptidomimetics . A Dissertation . Submitted to the Graduate Faculty of the . University of New Orleans . in partial fulfillment of the . requirements for the degree of . Doctor of Philosophy . In . The Department of Chemistry . By . Jean-René Ella-Menyé

Synthesis and antibacterial activities of α ...

Synthesis of novel N-substituted β-hydroxy amines 4(a-j) and β-hydroxyethers 5(a-c) with chiral benzoxazine fluoroquinolones has been described. Benzoxazinefluoroquinolone carboxylic acid 1, on reaction with piperizine in acetonitrile in presence of triethylamine under reflux gives 7- piperazinyl benzoxazine fluoroquinolone 2. The latter is reacted with epichlrohydrine in presence of NaOH in ...

Synthesis, resolution, derivatization and antibacterial ...

Thus, the identifications of new antibiotics specifically directed to E. faecalis may be envisaged. In this paper, a new series of N -1,3-benzothiazol-2-ylbenzamides have been designed, synthesized, and evaluated for their in vitro antimicrobial activities. Among the tested compounds, 3i was active against E. faecalis .

Synthesis, Characterization and Antibacterial Activity of ...

A series of D-glucosamine derivatives were synthesized (2–4) and evaluated for their antimicrobial activity. Some of the compounds investigated have shown significant antimicrobial activity against Gram-positive and Gram-negative bacterial strains as well as a few fungal strains. The results suggest that the presence of sugar moiety is necessary to biological activity.

Synthesis and antibacterial activity of novel lincomycin ...

Chiral aliphatic heterocycles are important structural feature of many pharmaceutical agents. Antibiotic resistance is a serious medical problem, therefore new antibacterial compounds are urgently needed. Herein, we describe synthesis of a series of 3,4‐disubstituted pyrrolidine derivatives via organocatalytic Michael addition followed by ...

Synthesis and Antibacterial Activities of Thiadiazole ...

Synthesis of carbazolophane amides along with their antibacterial and antifungal activities has also been reported (Ghose, 1999). Derivatives of tartaric acid with amide and ester bond, possess interesting biological activities such as anti-inflammatory (Dai, 2011) antifungal (Behr, 2003) antimicrobial (Kucuk,

Synthesis, Charecterization And Antibacterial Activity of ...

The N-isopropyl, N-isopentyl, and N-(2-phenylethyl) amides 11b, 11d and 11g were the most active and selective against Mycobacterium smegmatis (MIC = 8 µg/mL) with 11b and 11g displaying negligible or no cytotoxicity against HepG2 and A549 cells. Thirteen analogs of N-isopropylamide 11b were also synthesized and their antibacterial activity assayed. Results show that the difluoromethyl moiety ...

Synthesis and Antibacterial Activity of Isatin Schiff Base ...

The new compounds were screened for antimicrobial activities against six common strains of Gram-negative and Grampositive bacteria. The results of the present work show low to moderate antibacterial activity for the studied compounds. January March 2019 25 JCPS Volume 12 Issue 1 Synthesis and antibacterial activity of some novel sebacic acid derivatives Hossein Mostafavi*, Ameneh Abolgasemi ...

Synthesis and X-ray diffraction data of N 1,N 2-di(2 ...

et al 1 have reported the synthesis, complexation, antifungal and antibacterial activity studies of a new macro cyclic Schiff base (Scheme1). Preparation, physical characterization and antibacterial activity of Ni (II) Sciffbase complex was reported by Morad et al 2 (Scheme 2). OH H O H2N HO O H N OH H OO + Scheme-2 Elzahany et al 3 have synthesized some transition metal complexes with Schiff ...

Synthesis, antifungal and antibacterial activity for novel ...

Synthesis of Some New Linear and Chiral Macrocyclic Pyridine Carbazides as Analgesic and Anticonvulsant Agents Abdel-Galil E. Amr Applied Organic Chemistry Department, National Research Center, Cairo, Egypt Reprint requests to Abd El-Galil E. Amr. E-mail: aamr@yahoo.com Z. Naturforsch. 60b, 990–998 (2005); received March 16, 2005 A series of 2,6-disubstituted pyridine derivatives were ...

New N,N,N’,N’-tetradentate Pyrazoly Agents: Synthesis and ...

A. Heydari, M. Mehrdad, A. Maleki, N. Ahmadi, Synthesis, 2004, 1557-1558. Sc(OSO 3 C 12 H 25) 3 catalyses the asymmetric ring opening of meso-epoxides with aromatic amines in the presence of 1.2 mol-% of a chiral bipyridine ligand to afford β-amino alcohols in high yields with excellent enantioselectivities using water as environmentally benign solvent. S. Azoulay, K. Manabe, S. Kobayashi ...

Enantioselective cyanation via radical-mediated C–C single ...

The objective of the present work is to synthesize a new series of N'1, N’2 -bis [2-oxoindolin-3-ylidene] phthalohydrazides) for antioxidant activity. All the compounds were screened by DPPH method. The results of this study revealed that all synthesized compounds significantly scavenged DPPH free radicals in a concentration dependent manner. The IC50 values of all test compounds were found ...

Synthesis and Evaluation of Antibacterial Activity of ...

Synthesis of Some N(7)-Azacyclohexyl-4-oxothieno[2,3-b] ... sis and the antibacterial activity of a new series of 2-chloro-4-oxothieno[2,3-b] pyridine-5-carboxylic esters 8a–c and acids 9a–c having selected azacyclohexyl appendages and related congeners at the N(7) locus (Scheme 1). Herein, the choice is confined to piper-azino, morpholino, piperidino, N,N-dimethylamino, chiral alaninol ...

(DOC) SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF NEW N-R ...

Di Cesare P, Bouzard D, Essiz M, Jacquet JP, Ledoussal B, Kiechel JR, Remuzon P, Kessler RE, Fung-Tomc J, Desiderio J. Fluoronaphthyridines and -quinolones as antibacterial agents. 5. Synthesis and antimicrobial activity of chiral 1-t-butyl-6-fluoro-7-substituted-naphthyridones. J Med Chem, 1992, 35: 4205–4213. CrossRef Google Scholar

Antibacterial Activity of New Oxazolidin-2-One Analogues ...

Synthesis of carbazolophane amides along with their antibacterial and antifungal activities has also been reported [9]. In the continuation of our research work on biologically active compounds [10-12] and owing to the importance of amides in organic synthesis, we aimed to synthesize some amides from L-tartaric acid and their biological screening.

Eugenol derivatives: synthesis, characterization, and ...

As a continuation of our studies on the synthesis and biological activity of fused thieno[3,2-d]pyrimidine derivatives, the goal of this paper is the synthesis and study of the properties of compounds containing different heterocycles such as fused thieno[2,3-b]pyridine and tetrazolo[1,5-c]pyrimidine in the same molecule. Thus, starting from the ethyl 1-amino-5-isopropyl-8,8-dimethyl-8,9 ...


Synthesis And Antibacterial Activity Of New Chiral N



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Synthesis And Antibacterial Activity Of New Chiral N